IN-SILICO MOLECULAR MODELLING, MM/GBSA BINDING FREE ENERGY AND MOLECULAR DYNAMICS SIMULATION STUDY OF NOVEL PYRIDO FUSED IMIDAZO[4,5-C]QUINOLINES AS POTENTIAL ANTI-TUMOR AGENTS

With an alarming increase in the number of cancer patients and a variety of tumors, it is high time for intensive investigation on more efficient and potent anti-tumor agents.Though numerous agents have enriched the literature, still there exist challenges, with the availability of different kangertech subvod leaking targets and possible cross-reac

About 112 million working equids are the source of income for 600 million people globally.Many equids are used for pulling loads (up to 15,000 kg per day) to transport goods.Most of them are associated with brick kilns, mining, and agriculture industries in developing countries.They may suffer from welfare issues such as overloading, being beaten,

The application of a joint method of recording seismic and infrasound signals generated during ice calving from the terminal part of the outlet glaciers to identify the process of iceberg formation is considered.For many years, the Kola Branch of the Geophysical Service of the Russian Academy of Sciences has been developing technology for remote mo

Abstract In the present study, a series of 2-(4-(2-chloroacetyl)piperazin-1-yl)-N-(2-(4-chlorophenyl)-4-oxoquinazolin-3(4H)-yl)acetamide derivatives was synthesized and its chemical structures utvara hellkite price were confirmed by physicochemical and spectral characteristics.The synthesized compounds were evaluated for their in vitro antimicrobia

Sarcomeres are the smallest functional contractile unit of muscle, and myofibrils are striated muscle organelles that are comprised of sarcomeres that are strictly aligned in series.Furthermore, passive forces in sarcomeres and myofibrils are almost exclusively produced by the structural protein titin, and all contractile, regulatory, and structura